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Rui-Ping Xiao  

Editor, The New England Journal of Medicine, USA

Dr. Rui-Ping Xiao has been working in the Laboratory of Cardiovascular Science since February 1990. She was trained as a physiologist and molecular pharmacologist at Tong-Ji Medical University, China, and at the University of Maryland, where she received her M.D. and Ph.D., respectively.

Research Interests: Her main scientific focus has been related to receptor-mediated transmembrane signal transduction in the cardiovascular system. In addition, considerable efforts have been put on cardiac aging and heart failure associated changes in G-protein coupled receptor signaling. The breadth of our work covers four different areas: (1) signal transduction mechanisms which underlie the distinct functional roles of b-adrenergic receptor (AR) subtype stimulation in cardiac myocytes; (2) age-and heart failure-related alterations in cardiac responses to b-AR subtype stimulation; (3) interaction of the b-adrenergic signaling pathway with other cardiac sarcolemmal receptor mediated signaling pathways (e.g., opioid, adenosine, and acetylcholine receptors); and (4) the role of Ca2+/calmodulin-dependent kinase II (CaMKII) in cardiac functional regulation. Most studies are designed to integrate information gleaned from genetic manipulations, including gene transfer by adenoviruses, transgenic and gene targeted animal models, in conjunction with electrophysiologic, confocal imaging and cell biological techniques. The mechanistic and interdisciplinary nature of our research has made the past few years particularly fruitful.

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