Ho is a social-media fitness entrepreneur who established oGorgeous and has a YouTube channel called "Blogilates." Ho told Forbes that she receives a significant portion of her income directly and indirectly from her YouTube channel. She is one of a number of YouTube partners who are making a significant amount of money using YouTube. Her "Blogilates" channel, on which she is a Pilates instructor, has an e-commerce feature that allows her to sell her line of Pilates clothes and accessories such as exercise tops and bottoms, mats, and bags. She also makes money from Google ads on her YouTube channel. Ho told ABC News that as a result of the partners program at YouTube, she has a six figure income.

Her first fitness DVD, "POP Pilates: Total Body Workout," was released in Target stores in 2014 and her book, "Cassey Ho’s Hot Body Year-Round: The Pop Pilates Plan to Get Slim, Eat Clean, and Live Happy Through Every Season," was released in April 2015, published by Random House. She has also gone beyond Blogilates and hosted Pop Pilates, which is an in-person meet-up of up to 500 women who work out with her (she also does autograph signing and allows picture taking at these events). She has opened up a line of activeware on shopblogilates.com. Her designs have been featured in "Shape Magazine," "Fitness Magazine," and the "The Wendy Williams Show." In January 2016, Ho launched a new fashion line called "Popflex."

In 2017, Ho was listed in Time's third annual list of "The 25 Most Influential People on the Internet"

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