Chiara de Blasio is the first daughter of New York City. She attended the Beacon School in Hell's Kitchen, and studied Criminal Justice and Women's and Gender Studies at Santa Clara University in California. De Blasio now works as a program coordinator for a feminist group at Santa Clara's Community Action Program, a "community-based, service organization dedicated to applying activism and justice to address social issues in and around the campus community".

De Blasio said she sought treatment for substance abuse in a candid YouTube video from 2013. In 2014, her online essay on the now-defunct website xoJane about depression and addiction was recognized by the national Substance Abuse and Mental Health Services Administration for "serving as an example of hope for other young adults".

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