Christina Applegate is an Emmy Award-winning actress and a breast cancer survivor and advocate for its early detection.

She made her acting debut at three months old on the daytime soap opera "Days of Our Lives" in her mother's arms.

After performing in commercials for K-Mart and appearing in several movies and TV shows, she received her breakthrough role as teen airhead Kelly Bundy on Fox's popular sitcom "Married... With Children" at age 15. After an impressive 11 seasons, the show ended in 1997.

In 1998, she starred opposite Mark Wahlberg in the Hong Kong-tinged action-comedy he Big Hit and played the fiancee of a Mob scion in the Mafia parody, Mafia!.

Inspired by her experience with her own mother growing up, Applegate returned to TV in 1998 to star as a single mom balancing work and family in the sitcom "Jesse." The show won a People's Choice award in 1999.

Following her return to movies in 2001 with the time-travel comedy "Just Visiting," Applegate managed to hold her own opposite some of her more respected film peers. She received strong reviews as Cameron Diaz's levelheaded best friend in The Sweetest Thing in 2002, appeared with Gwyneth Paltrow in the flight attendant comedy View From the Top, and starred opposite Will Ferrell in Anchorman.

In the summer of 2008, Applegate was diagnosed with an early form of breast cancer. Due to early detection through an MRI, the cancer was not life-threatening; however, Applegate elected to have a double mastectomy due to her family history of breast cancer. Applegate started a program to help women at high risk for breast cancer to meet the costs of an MRI, which is not always covered by insurance.

In doing so, she has joined fellow survivors Sheryl Crow and Susanne Somers as a well-respected champion of breast cancer awareness.

From 2007 to 2009, she starred as Samantha, a woman who suffered amnesia and had to learn who she was again on the ABC sitcom "Samantha Who?." She also appeared in movies like "The Rocker" and "Going the Distance."

Applegate starred in the hit sitcom "Up All Night," playing the role of a working mother, opposite Will Arnett, who plays her stay-at-home husband.

Applegate currently co-stars in the dark comedy Netflix series "Dead to Me" alongside Linda Cardelli.

In August 2021, Applegate announced that she had been diagnosed with multiple sclerosis a few months prior.

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