Christina Applegate is an actress known for her roles in multiple award-winning television shows and films. Her most widely recognized role was as Kelly Bundy in the comedy sitcom "Married... With Children." This role catapulted Applegate into the public eye, and she has continued to create a substantial body of work in the entertainment industry. Her film roles have included key parts in Don't Tell Mom the Babysitter's Dead, Anchorman: The Legend of Ron Burgundy, and Bad Moms.

In addition to her film work, Applegate has excelled in television roles, such as the title character in the sitcom "Jesse," which earned her a Golden Globe Award nomination. She has also been recognized for her guest role in the NBC sitcom "Friends," for which she received a Primetime Emmy Award. Applegate's role in the sitcom "Samantha Who?" has led to multiple nominations for Primetime Emmy Awards and Golden Globe Awards. She has similarly been lauded for her work in the dark tragicomedy series "Dead to Me," receiving three Primetime Emmy Award nominations and a Golden Globe nomination.

Applegate has shown her versatility as a performer by successfully taking on roles in musical theatre. She earned a nomination for the Tony Award for Best Actress in a Musical for her role in the Broadway revival of "Sweet Charity." In addition to her acting roles, Applegate co-hosts a podcast titled "MeSsy" alongside Jamie-Lynn Sigler, discussing their shared experience of living with multiple sclerosis.

Off screen, Applegate has been open about her health struggles. She was diagnosed with breast cancer in 2008 and underwent a double mastectomy. She carries a BRCA1 mutation, a genetic trait associated with higher risks of breast and ovarian cancer. In 2021, she announced that she had been diagnosed with multiple sclerosis. Despite these challenges, Applegate continues to work both on and off screen, including lending her voice to characters and working behind the scenes.

Applegate's philanthropic endeavors are extensive. She has supported various causes, notably breast cancer education and research, through organizations such as the Entertainment Industry Foundation and the Lee National Denim Day. In 2009, she founded Right Action for Women, a charitable foundation focused on breast cancer screening. This commitment to philanthropy earned her the Saint Vintage Love Cures Award in 2015 for her dedication to and work with Right Action for Women. In recognition of her career and contributions, Applegate received a star on the Hollywood Walk of Fame in 2022.

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