Curtis Flowers is an American man who was tried for murder six times in the U.S. state of Mississippi. Four of the trials resulted in convictions, all of which were overturned on appeal. Flowers was alleged to have committed the July 16, 1996, shooting deaths of four people inside Tardy Furniture store in Winona, seat of Montgomery County. Flowers was first convicted in 1997; in five of the six trials, the prosecutor, Montgomery County District Attorney Doug Evans, a Democrat, sought the death penalty against Flowers. As a result, Flowers was held on death row at the Parchman division of Mississippi State Penitentiary for over 20 years.

In his first trial, Flowers was convicted of the aggravated murder and robbery of the store owner. This verdict and a conviction in a second trial for the murder of one of the store employees were both overturned by the Mississippi Supreme Court due to prosecutorial misconduct. A subsequent trial for all four murders resulted in conviction, but this was overturned by the Mississippi Supreme Court for racial bias by the prosecutor in jury selection: Flowers is black and the prosecution excluded a disproportionate number of black jurors. Flowers' fourth and fifth trials ended as mistrials. On June 18, 2010, a majority-white jury in Flowers' sixth trial convicted him of the 1996 murders and voted to impose a death sentence.

Flowers' case was one of three that the U.S. Supreme Court ruled in June 2016 were to be remanded to lower courts to be reviewed for evidence of racial bias in jury selection. After the Mississippi Supreme Court reaffirmed the conviction, the U.S. Supreme Court again reviewed Flowers' case. It overturned, on a 7–2 vote, the murder convictions in June 2019 in the decision Flowers v. Mississippi, with conservative Justice Brett Kavanaugh writing for the 7–2 majority. In December 2019, Flowers was released from prison for the first time since his original arrest, on $250,000 bond, pending a state decision on whether it would attempt another prosecution. On September 4, 2020, Mississippi Attorney General Lynn Fitch, a Republican who had taken over the case from District Attorney Evans, announced she would not seek a seventh trial and had dropped the charges against Flowers.

The Flowers case served as the subject of a 2018 podcast, In the Dark, on American Public Media.

Flowers said he hopes the story can help others who are innocent but sitting in prison seek justice. He started the Curtis Flowers Foundation to help people navigate the criminal justice system and to help young people interested in law get the education they need to pursue these cases.

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