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Eugenio Derbez was born in Mexico City, Distrito Federal, Mexico, the son of actress Silvia Derbez and publicist Eugenio González Salas. Derbez developed an early childhood interest in acting and made his television debut at 12, acting as an extra in a telenovela. Derbez kept acting during his school years and took his first formal acting class at age 19. During the early 1980s, Derbez was a regular in "Cachún Cachún Ra Ra!," a Mexican television show. He also participated in "En Familia con Chabelo," a children's television show.
In 1988 Derbez got his first recurring television position when he played a number of roles in a comedy show called "Anabel." In 1987, he briefly worked in a television series named "Tal Como Somos" ("Just The Way we Are"). In 1990, he played Eugenio in the comedy film "Transplante a la Mexicana" ("Mexican Style Transplant"). That same year he participated in "Fotógrafo de Modelos" ("Models Photographer"). In 1992 he began hosting the variety show "Al Derecho y al Derbez."
In 1997 Derbez made his directing debut in a soap opera named "No Tengo Madre" (Literal translation: "I Don't Have a Mother" meaning "I'm such a mess"). In 1999 Derbez started a new show, "Derbez en Cuando." In 2003, Derbez produced a television series named "XHDRBZ." He later produced "Hospital el Paisa" ("Countrymen Hospital"), "Vecinos" ("Neighbors") and in 2009 "Ellas son... la alegría del hogar" ("The Disorderly Maids of the Neighborhood").
He was the leading man in "La familia P. Luche," about a family whose possessions are made entirely of plush. He plays Ludovico P. Luche. The show is a spin-off of a segment of his variety show, "XHDRBZ." In 2004 he appeared on Adal Ramones' show, "Otro Rollo," and in 2005, Derbez was the host of Univision's "Premio Lo Nuestro" ceremony. In 2006 Derbez directed a play titled "La bella y la muy bestia" (the beauty and the most beast) by Mariano Moro at Repertorio Espanol in New York.
In 2011, Derbez starred in "Jack and Jill" as Felipe, which also starred Adam Sandler, Katie Holmes and Al Pacino.
In 2013 he starred in and directed "Instructions Not Included," which is the highest grossing Spanish-language film in U.S. history.
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