George Lopez’s multi-faceted career encompasses television, film, standup comedy, and late-night television. Lopez has completed several tours, including his stand up comedy tour, The Wall World Tour, in arenas across the country, and The Comedy Get Down, with Eddie Griffin, D.L. Hughley, and Cedric the Entertainer. The comedians also debuted their BET scripted comedy series based on their tour.

Lopez starred in Lopez on TV Land. Produced by Lopez, the series explored how he struggled between his two worlds and crises that are often of his own making. For two seasons Lopez hosted "Lopez Tonight," a late-night television talk show on TBS. This represented Lopez's return to series television after co-creating, writing, producing, and starring in Warner Bros. Television's groundbreaking hit sitcom "George Lopez," which ran for six seasons on ABC. In 2015, Lopez was seen in the Lionsgate inspirational drama, "Spare Parts." Produced by Lopez, the film is based on a true story about four undocumented Mexican-American teenagers from Phoenix who team up to build an underwater robot that wins the national robotics competition. In 2014, Lopez starred in the multi-camera ensemble comedy "Saint George" on FX, which he co-created. He has also been a voice actor on various animated films, including "Rio."

Lopez has been featured in three HBO specials, "The Wall" in August 2017, Grammy nominated Best Comedy Album "Tall, Dark and Chicano" in 2009, and "America's Mexican" in 2007. His acclaimed comedy concert, "Why You Crying?" debuted on Showtime in 2004. He released his third standup CD, "El Mas Chingon," in 2006, which also earned Lopez a Grammy nomination in the category of Best Comedy Album. In May 2004, Lopez’s autobiography, "Why You Crying?" entered The New York Times Bestsellers List top 20. The book was co-written by Emmy winning writer and sportscaster Armen Keteyian. Lopez released his second memoir, "I’m Not Gonna Lie And Other Lies You Tell When You Turn 50," in 2013 where he tells the unabashed and hilarious truth about aging. Lopez was also the focus of the award-winning documentary "Brown is the New Green: George Lopez and the American Dream."

In 2006, Lopez received a star on the Hollywood Walk of Fame. In addition, Time named him one of the 25 Most Influential Hispanics in America, and the Harris Poll named him one of the Top Ten Favorite Television Personalities.

Lopez’s wife donated a kidney to him in 2005, but the couple are now divorced. Lopez suffered from a genetic condition that caused his kidneys to deteriorate, and needed the transplant in order to survive. Since then, he has spread the word about the need for early detection of kidney disease and the critical shortage of donated organs for transplantation.

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