Jake Weber is known in film for his role as Michael in Dawn of the Dead and for his role as Drew in Meet Joe Black. In television, he is known for playing Joe DuBois, husband of psychic Allison DuBois, in the long running drama series Medium.

In 2001 and 2002, Weber was a series regular in HBO's The Mind of the Married Man and made guest appearances on Law & Order: Criminal Intent and NYPD Blue. As of autumn 2016, Weber joined the cast, in a recurring role, of ABC's Secrets and Lies in its second season. After a recurring role on Fox's The Following, Weber has had series regular roles on Hell on Wheels and Homeland.

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