Kevin Esvelt is an assistant professor at MIT Media Lab, where he leads the Sculpting Evolution group in exploring evolutionary and ecological engineering. After receiving his PhD at Harvard for inventing a synthetic microbial ecosystem to rapidly evolve useful biomolecules, he held two fellowships at Harvard and helped pioneer the development of CRISPR, a new method of genome engineering. In 2013, Esvelt was the first to identify the potential for CRISPR “gene drive” systems to alter wild populations of organisms. An advocate of open science to accelerate discovery and improve safety, he seeks to use gene drive as a catalyst to reform the scientific ecosystem.

Kevin Esvelt is director of the Sculpting Evolution group, which invents new ways to study and influence the evolution of ecosystems. By carefully developing and testing these methods with openness and humility, the group seeks to address difficult ecological problems for the benefit of humanity and the natural world.

Prior to joining the MIT Media Lab, Esvelt wove many different areas of science into novel approaches to ecological engineering. He invented phage-assisted continuous evolution (PACE), a synthetic microbial ecosystem for rapidly evolving biomolecules, in the laboratory of David R. Liu at Harvard University. At the Wyss Institute, he worked with George Church to develop the CRISPR system for genome engineering and regulation, and he began exploring the use of bacteriophages and conjugation to engineer microbial ecosystems.

Esvelt is credited as the first to describe how CRISPR gene drives could be used to alter the traits of wild populations in an evolutionarily stable manner. And recently, he and his Sculpting Evolution group devised a new form of technology, called ‘daisy drives’, which would let communities aiming to prevent disease alter wild organisms in local ecosystems.

By emphasizing universal safeguards and early transparency, he has worked to ensure that community discussions always precede and guide the development of technologies that will impact the shared environment. Events

Professors, Science, Technology, Thought Leadership