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Michael Rafii  

Professor, Medical Director, Alzheimer's and Down Syndrome researcher

Michael Rafii is a board-certified neurologist and Associate Professor of Clinical Neurology at the Keck School of Medicine of the University of Southern California (USC). He is Medical Director of the Alzheimer’s Therapeutic Research Institute (ATRI) and the NIH-funded Alzheimer’s Clinical Trial Consortium (ACTC) where he leads a team of 4 physicians and 20 clinical monitors who oversee safety across all clinical trials. He received his MD and PhD degrees from Brown University School of Medicine and conducted neurogenetics research at Harvard Medical School. Dr. Rafii completed his Neurology residency at the Johns Hopkins Hospital where he also served as chief resident. He then completed a fellowship in dementia at UC San Diego.

Dr. Rafii’s research focuses on the design and conduct of multi-center clinical trials (phase I-III) for Alzheimer's disease, including a genetic form of AD which occurs in Down syndrome. He was principal investigator of the Down Syndrome Biomarker Initiative (DSBI) and serves on the steering committee for the NIH-funded Alzheimer's Biomarker Consortium - Down syndrome (ABC-DS). Dr. Rafii is co-editor of the textbook 'Common Pathogenic Mechanisms between Down Syndrome and Alzheimer's Disease: Steps toward Therapy’ and author of the book ‘First Aid for the Neurology Boards.’ He is a scientific reviewer for the National Institutes of Health and the Alzheimer's Association. Dr. Rafii’s work has been featured in the New York Times, Chicago Tribune, Wall Street Journal and National Public Radio (NPR).

Previously, Dr. Rafii served as Medical Director of the Alzheimer’s Disease Cooperative Study (ADCS), Director of the Memory Disorders Clinic, Founding Director of the Adult Down Syndrome Clinic and Director of the Neurology Residency Training program at UC San Diego


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