Weitz first achieved mainstream success by directing American Pie with his brother Chris. He then co-directed 2002's About a Boy, an adaption of Nick Hornby's novel which was Weitz's greatest critical success and earned him and his brother an Academy Award nomination for Best Adapted Screenplay. The brothers have since worked on establishing separate film careers, although they often serve as a producers on each other's projects. Weitz has written and directed two films by himself: the well-received romantic comedy In Good Company and the political satire American Dreamz, which faced mixed reviews. Additional writing credits include Antz and the television show Cracking Up.

He has also directed an adaptation of Darren Shan's young adult novel Cirque du Freak called The Vampire's Assistant. He directed the 2010 film Little Fockers, the sequel to Meet the Parents, and Meet the Fockers.

Jewish, Religious, Religious speakers, Jewish Heritage,