After a brief appearance in Nick Ross's documentary series The Truth About Crime, de Souza got his break on television at the age of 17, when he was cast as Matty Levan in the fifth and sixth installment of cult drama Skins. In 2012, he joined the cast of historical drama The Borgias. While in Hungary, he was a filmmaker with photographer Benjamin Lebus for Evelyne's World, a concept short film about the allegory of the Cave starring Évelyne Brochu.

De Souza's first big screen role is in Julian Gilbey's thriller Plastic. As a screenplay writer, he is set to make his cinematic debut in Kids in Love, a film produced by Ealing Studios with de Souza also taking a title role alongside Will Poulter, Alma Jodorowsky and Cara Delevingne. In 2014 he was cast as the male lead in a new series based on Blake Nelson's novel Recovery Road, which will premiere in 2016.

In addition to his acting career, de Souza is a singer and musician. In 2011 he's featured as a guest vocalist for Cubiq in their Say EP released by Hidden Label. The tune, related to current electro club music, has been remixed by Matanza and Timmy P[19] in an alternative version that fits the traditional house template.

De Souza also works in the field of producing. In 2013 he co-founded with actor Will Poulter the TV and film production company Good Soil. The following year he created his own brand management called de Souza aimed at helping young storytellers, producers or filmmakers develop their scripts.

Actors, Entertainment Industry, Television Actor, British / English, Movie Actor, Screenwriter, Screenwriting, Entertainers, Producers and Directors, Filmmaking, Producing, Television & Film Directing, Acting,