Waterhouse was born in Hammersmith, London, England, and was raised in Chiswick, London, the daughter of Elizabeth, a cancer care nurse, and Norman Waterhouse, a plastic surgeon. She has a younger sister, Imogen, known as Immy, who is also a model.

Waterhouse began her modelling career after being discovered in a pub in London when she was 16. When she was 19, her first noted campaign was as a lingerie model for Marks and Spencer.

She is a face of Burberry and Redken. Waterhouse has also modelled for brands like Tommy Hilfiger (alongside sister Immy), Swatch, Lucy in Disguise, H&M, Alice + Olivia, Coast, Max Studio, Sass & bide, Caterina Gatta and Pepe Jeans.

Waterhouse has appeared on the cover of British, Korean, Thai, Taiwanese and Turkish Vogue, Tatler, British and Korean Elle as well as Lucky, L'Officiel, American "Marie Claire", French Grazia and 1883 Magazine. Waterhouse has also shot editorials for American, Chinese, Russian, and Japanese "Vogue" Love Magazine, American Elle, Velour, and Stylist Magazine among others. Waterhouse has also walked the runway for brands including Burberry and Balenciaga and is a regular on the front row at fashion week.

Models, Modeling, Fashion Model, Actress, Entertainers, British / English, Lifestyle Actors, Acting,