In 2010 Clayton was the makeup artist and co-host on VH1's first makeover show TRANSform Me. The following year she played the recurring role of Kyla in the third season of the HBO series Hung. In 2012 Clayton played the lead role of Michelle Darnell on the Emmy Award winning interactive web series Dirty Work and the role of Carla Favers on the TV series Are We There Yet? She also narrated the audiobook for the young-adult George about a young trans girl.

Clayton currently stars as one of the eight main characters in the Netflix original television series Sense8 that premiered on June 5, 2015. In Sense8 she plays Nomi Marks, a San Francisco transgender female political blogger and hacker.

She is due to appear in the upcoming 2016 movie The Neon Demon.

Transgender, LGBTQ, Television Actress, Actress, Actors, Acting,