Lowell was born in Atlanta, Georgia. He attended the Atlanta International School, where he became interested in theatre and filmmaking. In his spare time, he enjoys amateur filmmaking, theatre, and traveling.

In 2003 after going through his first major audition, he landed a role on the ABC teen drama "Life As We Know It." Of the show's trio of male characters, Lowell portrayed Jonathan Fields, the "least confident but most creative and grounded of the three."

In 2006, Lowell had lead roles in the coming-of-age film "Graduation" and also in a small film entitled "You Are Here." After the end of "Life As We Know It," Lowell was cast as Stosh "Piz" Piznarski in the third season of "Veronica Mars," opposite Kristen Bell and Jason Dohring.

From 2007-2010, Lowell appeared in the ABC drama "Private Practice," alongside Kate Walsh, Audra McDonald and Tim Daly, playing Dell, the receptionist for the Oceanside Wellness Group who is also a qualified nurse, midwife-in-training, and young father to six-year-old daughter Betsy. Lowell exited "Private Practice" in the show's third season finale when Dell died from heart failure, a complication during brain surgery after a vehicle accident.

In 2011, Lowell played the role of Stuart Whitworth in the movie, "The Help." Stuart was Skeeter's (Emma Stone's) love interest in the movie.

Lowell stars in the upcoming FOX series "Enlisted," a comedy that follows three very different brothers working together in the Army at a small base in Florida.

Lowell is vocalist and harmonicist for the indie acoustic band Two Shots for Poe.